ABSTRACT
This study was conducted to determine the objective role of antiviral drugs such as arbidol, lopinavir/ritonavir, and others in improving clinical symptoms, decreasing duration of hospitalization, and decreasing duration of viral shedding in patients with mild and moderate COVID-19 infection. A systematic literature search was carried out on Google Scholar and PubMed databases, using the keywords "COVID-19”, "Antiviral”, "Treatment”, and "Symptomatic” in various combinations. Observational studies, cohort and case control studies, and clinical trials published in English with full-text available were included in the study. Data extraction was carried out from selected studies, and all statistical analysis for the study was carried out using Microsoft Excel. The key outcomes studied were time to negative PCR, duration of clinical stay, time to clinical improvement, and occurrence of adverse events. Seven studies were selected for final review after rigorous selection process. Data of total 4734 participants was analyzed, the majority of which were females (n=2810, 59.3%). The majority of participants had mild disease (n=4197, 88.65%). Average time for negative RT-PCR in the included treatment groups was 13.5 days, whereas the average duration of hospitalization was 14.9 days for the treatment groups. Adverse reactions such as ECG changes, gastrointestinal symptoms, secondary bacterial infections, and hepatic and renal dysfunction were scarcely reported in the included studies. There is no clear benefit in terms of duration of hospitalization and time to negative PCR with the use of various antiviral regimens in mild disease;however, these drugs did play a role in limiting disease progression in the participant population. Pending further evidence, the use of these drugs for the management of COVID-19 is not recommend in patients with mild disease. © 2022, The Running Line. All rights reserved.
ABSTRACT
Purpose: Coronavirus Disease 19 has highly impacted the education system and created the trend of online classes. To fill in the gap created by lock down and to continue an uninterrupted learning process, educational institutions worldwide started organizing online classes. Although Medical education is mostly practice based but it was not safe to conduct on campus classes. This study aimed at measuring the scope and limitations of online education and the overall impacts of Coronavirus Disease 19 on the medical education system. Methodology: Cross-sectional study. Ethical approval was obtained from Ethical committee South Point Hospital. Informed consent was obtained. Self-administered questionnaires were given to the participants. Results: E-Learning opportunities were made available in 98.69% cases;some student forums also participated creating additional opportunities. Out of 260 students, 108 (41.1%) were males and 152 (57.8%) females. 29.3% belonged to Metropolitan Area, 28.9% to District Town, 16.3% to Upazila Town, 24.3% to village and 0.4% to unspecified areas. The quality of internet was reported as excellent, good, fair and poor. Only 1.9% of the students had more than 80% attendance. Zoom was used in 57.8% situations followed by Facebook live (15%) and was least for pre-recorded video upload, YouTube link etc. On investigation about quality of lectures, 8.7% people rated excellent while 75.7% students marked them fair to good and 14.8% rated as poor. 46.8% of students showed satisfaction towards online assessments and 44.5% students were not satisfied. Families of 57.4% respondents faced financial stress. 6.8% faced none whereas 29.3% students faced huge mental stress during Coronavirus Disease 19. Conclusions: E-learning is the new normal during Coronavirus Disease 19 pandemic. Given the opportunity, medical students although benefited a lot but there existed a technological divide. There were also financial and mental stresses to certain extent.
ABSTRACT
Aim: To review neurological aspects of patients infected with COVID-19 including neurological dysfunctions and possible pathophysiology. Methods: A systematic review of articlesfrom PubMed, Ovid MEDLIN, DOAJ databases and grey literature included the WHO-COVID-19 database, and medRxiv.Articles published from January 2020 until June 2020 were included in the review. Out of the226 titles and s, 213 were identified after the removing duplicates. With a screening of 119 studies carried by all authors, 83 full-text articles were assessed based on inclusion criteria of the neurological perspectives with COVID-19. Subsequently, 45 texts were removed. A total of 38 studies were included in the last scrutiny.Specifically, case reports, cohort studies, and case series were included Results: Reviewed evidence was presented in textual and tabulated format, which includes methodology, characteristics of included studies and summary of findings. Correlational evidence of COVID-19 disease and neurological dysfunctions with possible pathophysiology isreviewed. Conclusion:The findings provide evidence for physicians and neurologists working with COVID-19 patients about the possible probable complications and clinical presentations due to the SARS-CoV-2 infection.